GHK 50mg
$49.00
99%+ Purity
A copper-binding tripeptide (glycyl-histidyl-lysine + Cu²⁺) studied for collagen synthesis, gene expression modulation, and tissue-remodeling pathway research.
Batch and certificate of analysis
Current lot DPS-5065007 · 50 mg · tested August 6, 2026 · Horizon Analytical. The results below are from the certificate for this exact lot, not a representative sample.
| Parameter | Result | Method | Specification |
|---|---|---|---|
| Identity | GHK · Pass | UPLC/MS | Confirmed |
| Appearance | Blue lyophilized powder | Visual | Meets specification |
| Purity | 99.54% · Pass | UPLC/MS | Specification > 98% |
| Net content | 48.9 mg | UPLC/MS | Labeled 50 mg |
Certificates for every released lot of this product are on the COA page.
Research specifications
| Form | Lyophilised powder in a sealed glass vial |
| Labeled content | 50 mg |
| Appearance (current lot) | Blue lyophilized powder |
| Storage | Sealed vials cold, dry and protected from light; frozen for long-term storage |
| Intended use | Laboratory research only |
Identifiers
| Compound | GHK |
| Length | 3 amino-acid residues |
| Molecular formula | C14H24N6O4 |
| Molecular weight | 340.38 g/mol |
| CAS registry number | 49557-75-7 |
| PubChem CID | 73587 |
| Copper complex | C14H23CuN6O4+, 402.92 g/mol, PubChem CID 71587328, CAS 89030-95-5 |
Identifiers are the values PubChem lists for the named record, checked September 2026. Where PubChem lists no CAS number, none is shown.
Identity, composition and analytical documentation
Each released lot is tested by an independent laboratory (Horizon Analytical for the current lot). The certificate reports identity by mass spectrometry, purity by UPLC/MS, and net content measured against the labeled amount. A separate endotoxin report accompanies the certificate for this lot. The certificate does not include heavy-metal, sterility, residual-solvent or microbial testing. The lot number on the certificate is the lot number on the vial, so a certificate can be matched to the material in hand. Certificates for every lot released on this site remain available on the COA page.
Research overview
Findings below are from the cited laboratory and animal studies; nothing here describes effects in people.
Research Overview
GHK (Copper Peptide) is a naturally occurring tripeptide-copper complex (Glycyl-L-Histidyl-L-Lysine:Copper) first isolated from human plasma in the 1970s. The peptide binds copper(II) ions with high affinity (Kd ~ 10⁻¹⁶ M), forming a stable complex that is studied for its roles in tissue remodeling, extracellular matrix regulation, metalloproteinase signaling, and broad-spectrum gene expression modulation. Its natural occurrence in plasma, saliva, and urine at concentrations that decline with age has made GHK a focus of both tissue repair and aging-related research.
Gene Expression and ECM Remodeling
Gene expression studies have identified GHK as a modulator of over 4,000 human genes, with particular effects on genes governing collagen synthesis (COL1A1, COL3A1), glycosaminoglycan production, decorin expression, and matrix metalloproteinase (MMP) regulation. The copper ion component is studied for its catalytic role in lysyl oxidase (LOX) activation — the enzyme essential for collagen and elastin cross-linking that determines tissue structural integrity. GHK also supports superoxide dismutase (SOD) function, linking its copper-delivery mechanism to antioxidant defense pathways.
Comparative Tissue Repair Research
GHK is compared with other tissue-active peptides in research settings. Studies alongside Body Protection Compound 157 examine complementary mechanisms — GHK's extracellular matrix remodeling versus Body Protection Compound 157's cytoprotective and growth factor pathways. This distinction is significant: GHK primarily acts on the structural scaffold of tissue (collagen, elastin, proteoglycans), while Body Protection Compound 157 engages intracellular signaling cascades involving VEGF, FAK-paxillin, and nitric oxide systems. Researchers studying tissue repair often investigate both peptides to characterize upstream signaling versus downstream structural effects. The GLOW Blend combines GHK with complementary peptides for multi-pathway tissue research.
Laboratory applications include fibroblast proliferation and migration assays, wound healing scratch models, collagen gel contraction studies, extracellular matrix composition analysis (hydroxyproline and GAG quantification), MMP activity measurements (zymography), lysyl oxidase activity assays, and skin biology research. For sourcing guidance, see our Where to Buy GHK resource.
Explore the PeptidesATX Research Library for additional peptide pharmacology guides and reference resources.
GHK single compound compared with the blends that contain it
Rows describe composition and documentation, not effects.
| GHK 50mg | GLOW Blend 70mg | KLOW Blend 80mg | |
|---|---|---|---|
| GHK content | 50 mg, single compound | 50 mg with two other peptides | 50 mg with three other peptides |
| Form | Copper tripeptide complex, lyophilised | Blend, lyophilised | Blend, lyophilised |
| Certificate of analysis | Single-compound purity and identity | Per-component measured content | Per-component measured content |
Scientific references
- Pickart L, Margolina A. Int J Mol Sci. 2018;19(7):1987. PubMed 29986520
- Pickart L. J Biomater Sci Polym Ed. 2008;19(8):969–988. PubMed 18644225
Related research guides
- GHK research guide — copper binding and gene-expression research
- How to evaluate a GHK supplier — documentation, purity and traceability checklist
- GLOW research blend guide — GHK as a blend component
- Peptide half-life chart — reported plasma half-life
Frequently asked questions
- Which lot will I receive, and how do I check it?
- The lot shown on this page (DPS-5065007) is the one currently shipping; when a new lot is released, this page and the COA page update together. The lot number is printed on the vial label and matches the certificate.
- What does the certificate of analysis cover?
- Identity and purity by UPLC/MS from an independent laboratory (Horizon Analytical), measured net content against the labeled amount, and appearance, with a separate endotoxin report; both documents are linked above as PDFs. The certificate does not include heavy-metal, sterility, residual-solvent or microbial testing.
- What identifiers should match the certificate?
- The compound name, molecular formula and molecular weight in the compound information block are the values PubChem lists for this compound; the certificate reports identity by mass spectrometry against the same molecular weight.
- How should the vial be stored on receipt?
- Sealed lyophilised vials are kept cold, dry and away from light; long-term storage is frozen. The handling notes on this page and the storage guide give the laboratory practice in more detail.
- When does an order ship?
- Orders placed before the daily cutoff shown above ship the same business day from Austin, Texas, with tracking. Delivery estimates and the free-shipping threshold are shown in the order summary.