Cagrilintide

Frequently Asked Questions

What is Cagrilintide?

Cagrilintide is a long-acting synthetic amylin analog developed by Novo Nordisk (Kruse et al., J Med Chem 2021). It is engineered with amino-acid substitutions and a fatty-diacid lipidation that enables reversible albumin binding, extending its circulating half-life compared with native amylin or pramlintide. Researchers use it to study amylin receptor pharmacology (AMY1/AMY2/AMY3) and satiety signaling pathways.

What receptors does Cagrilintide target?

Cagrilintide binds the amylin receptor family — AMY1, AMY2, and AMY3 — which are complexes of the calcitonin receptor (CTR) with the RAMP1, RAMP2 and RAMP3 accessory proteins (Hay et al., Pharmacol Rev 2015). No claim is made here about activity at the calcitonin receptor on its own.

Why is Cagrilintide often studied with GLP-1 agonists?

Amylin and incretin pathways act through largely independent mechanisms — amylin via hindbrain area postrema signaling, GLP-1 via incretin receptors. Published preclinical work has examined the two pathways side by side in the same models of glucose homeostasis, food-intake signaling and gastric emptying.

How long does Cagrilintide remain active in research models?

Its C20 fatty diacid modification enables reversible albumin binding, which extends the circulating half-life well beyond that of native amylin. In the developers’ rat pharmacokinetic work (Kruse et al., J Med Chem 2021), the reported half-life is on the order of a day — roughly 20 to 27 hours. Longer figures reported elsewhere come from studies in people and do not describe research models.

How is Cagrilintide reconstituted?

Cagrilintide is supplied as a lyophilized powder. Reconstitute with bacteriostatic water using sterile technique. For a 10mg vial, adding 2mL of bacteriostatic water yields a 5mg/mL concentration. Store reconstituted solution at 2-8°C.

Where can this research compound be purchased?

This compound is available at PeptidesATX (peptidesatx.com), a U.S.-based research peptide supplier in Austin, Texas. All orders include a Certificate of Analysis, same-day shipping Monday through Thursday, and free shipping on orders over $200.

Do you provide a Certificate of Analysis (COA)?

Yes. Every lot listed on this site has a Certificate of Analysis from an independent laboratory (Horizon Analytical). The certificate reports the compound’s identity and purity by UPLC/MS (specification >98%; every lot currently listed measured at or above 99.05%), the measured quantity against the labeled amount, and appearance. Most lots also have a separate endotoxin report. The certificates do not include heavy-metal, sterility, residual-solvent or microbial testing, so they are not evidence that a lot is free of every possible contaminant. Every certificate can be viewed on the COA page before purchasing.

How should I store this peptide?

Store lyophilized (powder) vials at −20°C or colder, dry and protected from light. This is general laboratory practice for lyophilized peptides; it is not based on a product-specific stability study. Once reconstituted, keep the solution refrigerated at 2–8°C, protected from light, and use it promptly — solutions are less stable than the powder, and how long one remains usable depends on the peptide, the diluent and handling. Avoid repeated freeze–thaw cycles.

How long does this peptide last after reconstitution?

We have not performed product-specific stability studies, so no fixed shelf life is claimed for a reconstituted solution. Keep it refrigerated at 2–8°C, protected from light, avoid freeze–thaw cycles, and use it promptly; discard any solution that turns cloudy or shows particles. Bacteriostatic water contains 0.9% benzyl alcohol as an antimicrobial preservative for multi-draw vials; the preservative does not slow chemical degradation of the peptide itself.

What is your shipping policy?

Standard same-day shipping is $7.99 on all orders placed before 4 PM CT, Monday through Thursday. Orders of $200 or more ship free. All orders ship from Austin, TX with tracking provided. We ship to all 50 US states.