MOTS 10mg

Frequently Asked Questions

What is MOTS?

MOTS (Mitochondrial Open Reading Frame of the Twelve S rRNA Type) is a mitochondrial-derived peptide encoded within the mitochondrial genome. It is the first MDP shown to translocate to the nucleus, making it a key research tool for studying mito-nuclear communication and retrograde mitochondrial signaling.

How does MOTS activate AMPK?

MOTS activates AMPK indirectly by inhibiting the folate-methionine cycle, which leads to accumulation of the intermediate AICAR (5-aminoimidazole-4-carboxamide ribonucleotide) — a well-characterized endogenous AMPK activator. This peptide-mediated mechanism is distinct from most pharmacological AMPK activators and provides a unique tool for metabolic research.

Why is MOTS studied as an exercise mimetic?

Physical activity has been shown to increase endogenous MOTS levels in research models. Exogenous MOTS activates overlapping metabolic pathways — including AMPK activation, enhanced glucose uptake, and increased fatty acid oxidation — leading researchers to investigate it as a model for understanding exercise-induced metabolic adaptations at the molecular level.

What makes MOTS unique among research peptides?

MOTS is encoded by the mitochondrial genome rather than nuclear DNA, making it one of very few known mitochondrially-encoded signaling peptides. Its ability to translocate to the nucleus under metabolic stress to regulate gene expression represents a novel signaling mechanism — direct retrograde communication from mitochondria to nuclear transcription.

Where can this research compound be purchased?

This compound is available at PeptidesATX (peptidesatx.com), a U.S.-based research peptide supplier in Austin, Texas. All orders include a Certificate of Analysis, same-day shipping Monday through Thursday, and free shipping on orders over $200.

Do you provide a Certificate of Analysis (COA)?

Yes. Every lot listed on this site has a Certificate of Analysis from an independent laboratory (Horizon Analytical). The certificate reports the compound’s identity and purity by UPLC/MS (specification >98%; every lot currently listed measured at or above 99.05%), the measured quantity against the labeled amount, and appearance. Most lots also have a separate endotoxin report. The certificates do not include heavy-metal, sterility, residual-solvent or microbial testing, so they are not evidence that a lot is free of every possible contaminant. Every certificate can be viewed on the COA page before purchasing.

How should I store this peptide?

Store lyophilized (powder) vials at −20°C or colder, dry and protected from light. This is general laboratory practice for lyophilized peptides; it is not based on a product-specific stability study. Once reconstituted, keep the solution refrigerated at 2–8°C, protected from light, and use it promptly — solutions are less stable than the powder, and how long one remains usable depends on the peptide, the diluent and handling. Avoid repeated freeze–thaw cycles.

How long does this peptide last after reconstitution?

We have not performed product-specific stability studies, so no fixed shelf life is claimed for a reconstituted solution. Keep it refrigerated at 2–8°C, protected from light, avoid freeze–thaw cycles, and use it promptly; discard any solution that turns cloudy or shows particles. Bacteriostatic water contains 0.9% benzyl alcohol as an antimicrobial preservative for multi-draw vials; the preservative does not slow chemical degradation of the peptide itself.

What is your shipping policy?

Standard same-day shipping is $7.99 on all orders placed before 4 PM CT, Monday through Thursday. Orders of $200 or more ship free. All orders ship from Austin, TX with tracking provided. We ship to all 50 US states.