IGF-1 1mg
$110.00
A modified IGF-1 analog with reduced IGFBP binding, studied for IGF-1R activation, PI3K/Akt signaling, and MAPK pathway research in cellular proliferation models.
Research Overview
IGF-1 LR3 (Insulin-like Growth Factor 1 Long R3) is a modified analog of human IGF-1 in which the glutamic acid at position 3 is replaced with arginine (R3) and a 13-amino acid extension is added to the N-terminus. These modifications significantly reduce binding to IGF binding proteins (IGFBPs), resulting in enhanced bioavailability and extended signaling duration compared to native IGF-1.
Researchers investigate IGF-1 LR3 to study IGF-1 receptor (IGF-1R) signaling pathways, including downstream PI3K/Akt and MAPK/ERK cascades that regulate cell proliferation, differentiation, and survival. The reduced IGFBP binding allows researchers to study IGF-1R activation without the confounding effects of binding protein sequestration that complicates native IGF-1 research.
IGF-1 LR3 is studied within the broader context of the GH-IGF-1 axis, where it serves as the primary mediator of growth hormone's anabolic and metabolic effects. Understanding IGF-1R signaling is central to research in cell biology, metabolic regulation, and tissue growth mechanisms.
Laboratory applications include cell proliferation assays, receptor phosphorylation studies, signaling pathway analysis, and growth factor concentration-response characterization in cell culture systems. Available in 1mg research preparations.
Explore the PeptidesATX Research Library for additional peptide pharmacology guides and reference resources.
Frequently researched together
Compounds studied alongside this one
Frequently Asked Questions
- Where can this research compound be purchased?
- This compound is available at PeptidesATX (peptidesatx.com), a U.S.-based research peptide supplier in Austin, Texas. All orders include a Certificate of Analysis, same-day shipping Monday through Thursday, and free shipping on orders over $200.
- How should I store this peptide?
- Store lyophilized (powder) vials at −20°C or colder, dry and protected from light. This is general laboratory practice for lyophilized peptides; it is not based on a product-specific stability study. Once reconstituted, keep the solution refrigerated at 2–8°C, protected from light, and use it promptly — solutions are less stable than the powder, and how long one remains usable depends on the peptide, the diluent and handling. Avoid repeated freeze–thaw cycles.
- How long does this peptide last after reconstitution?
- We have not performed product-specific stability studies, so no fixed shelf life is claimed for a reconstituted solution. Keep it refrigerated at 2–8°C, protected from light, avoid freeze–thaw cycles, and use it promptly; discard any solution that turns cloudy or shows particles. Bacteriostatic water contains 0.9% benzyl alcohol as an antimicrobial preservative for multi-draw vials; the preservative does not slow chemical degradation of the peptide itself.
- What is your shipping policy?
- Standard same-day shipping is $7.99 on all orders placed before 4 PM CT, Monday through Thursday. Orders of $200 or more ship free. All orders ship from Austin, TX with tracking provided. We ship to all 50 US states.
All products currently listed on this site are for research purposes only. U.S. sourced. Not intended for human dosing, injection, or ingestion.