99.2%
UPLC/MS purity · meets > 98%- Labeled
- 10 mg
- Measured
- 10.12 mg
- Identity
- Confirmed
- Endotoxin
- < 0.05 EU/mL
PT-141 10mg
$49.00
99%+ Purity
A cyclic heptapeptide α-MSH analog engaging MC3R and MC4R melanocortin receptors, studied for central neuroendocrine pathway research.
Verified test results
Every batch, independently tested.
Each lot is analysed by a third-party laboratory. The results below are from the certificate for this exact lot — not a representative sample.
| Parameter | Result | Method | Specification |
|---|---|---|---|
| Identity | PT-141 · Pass | UPLC/MS | Confirmed |
| Appearance | White lyophilized powder | Visual | Meets spec |
| Purity | 99.2% · Pass | UPLC/MS | > 98% |
| Net peptide content | 10.12 mg | UPLC/MS | 10 mg |
| Endotoxin | < 0.05 EU/mL | Endotoxin test | Reported |
Lot DPS-4394418 · analysed August 28, 2026 · Horizon Analytical
Certificate of Analysis
Third-party tested for purity
99.24%
UPLC/MS purity · meets > 98%- Labeled
- 10 mg
- Measured
- 10.18 mg
- Identity
- Confirmed
Research Overview
PT-141 is a synthetic cyclic heptapeptide that acts as a melanocortin receptor agonist, with primary affinity for the MC3R and MC4R receptor subtypes. Originally derived from the alpha-melanocyte stimulating hormone (α-MSH) analog MT-2, PT-141 was structurally modified to reduce melanocortin-1 receptor activity while retaining MC3R/MC4R selectivity. This selectivity shift — achieved by removing the linear N-terminal sequence and cyclizing the core pharmacophore — represents a key case study in peptide structure-activity relationship research.
Researchers investigate PT-141 to study melanocortin receptor signaling in the central nervous system, particularly MC4R-mediated pathways in the hypothalamus. The MC4R pathway is involved in multiple physiological processes including appetite regulation, autonomic nervous system modulation, and neuroendocrine signaling. PT-141's receptor selectivity profile makes it a useful pharmacological tool for dissecting the specific contributions of MC3R and MC4R activation without the confounding pigmentary effects mediated by MC1R.
Melanocortin Receptor Pharmacology
The melanocortin receptor family (MC1R through MC5R) regulates diverse biological functions ranging from pigmentation and adrenal steroidogenesis to energy homeostasis and inflammatory signaling. PT-141's preferential activation of MC3R and MC4R allows researchers to probe central nervous system melanocortin pathways independently of peripheral MC1R-mediated effects. MC4R activation triggers intracellular cAMP accumulation via Gs-protein coupling, initiating downstream signaling cascades involving PKA, CREB phosphorylation, and oxytocin neuron activation in the paraventricular nucleus. MC3R engagement, studied to a lesser extent, appears to modulate energy balance and autonomic output through distinct hypothalamic circuits.
Structure-Activity and Comparative Studies
PT-141 has been the subject of extensive published research providing well-documented receptor pharmacology and binding data that informs further research applications. Structure-activity relationship studies compare PT-141 against other melanocortin analogs — including its parent compound MT-2 and the endogenous ligands α-MSH, β-MSH, and ACTH — to understand how cyclic peptide modifications affect receptor selectivity, binding affinity, and signaling duration. These comparisons are valuable for researchers designing next-generation melanocortin-targeted compounds.
Laboratory applications include melanocortin receptor binding assays (radioligand displacement and fluorescence polarization), hypothalamic cell signaling studies, cAMP pathway activation measurements, calcium mobilization assays, and comparative pharmacology research across the melanocortin receptor family. PT-141 is supplied as lyophilized powder in 10mg vials with Certificate of Analysis included.
Explore the PeptidesATX Research Library for additional peptide pharmacology guides and reference resources.
Frequently researched together
Compounds studied alongside this one
Frequently Asked Questions
- What is PT-141?
- PT-141, also known as PT-141, is a synthetic peptide and melanocortin receptor agonist. It is derived from MT-2 and is used in research studying melanocortin receptor pathways.
- Where can this research compound be purchased?
- This compound is available at PeptidesATX (peptidesatx.com), a U.S.-based research peptide supplier in Austin, Texas. All orders include a Certificate of Analysis, same-day shipping Monday through Thursday, and free shipping on orders over $200.
- Do you provide a Certificate of Analysis (COA)?
- Yes. Every lot listed on this site has a Certificate of Analysis from an independent laboratory (Horizon Analytical). The certificate reports the compound’s identity and purity by UPLC/MS (specification >98%; every lot currently listed measured at or above 99.05%), the measured quantity against the labeled amount, and appearance. Most lots also have a separate endotoxin report. The certificates do not include heavy-metal, sterility, residual-solvent or microbial testing, so they are not evidence that a lot is free of every possible contaminant. Every certificate can be viewed on the COA page before purchasing.
- How should I store this peptide?
- Store lyophilized (powder) vials at −20°C or colder, dry and protected from light. This is general laboratory practice for lyophilized peptides; it is not based on a product-specific stability study. Once reconstituted, keep the solution refrigerated at 2–8°C, protected from light, and use it promptly — solutions are less stable than the powder, and how long one remains usable depends on the peptide, the diluent and handling. Avoid repeated freeze–thaw cycles.
- How long does this peptide last after reconstitution?
- We have not performed product-specific stability studies, so no fixed shelf life is claimed for a reconstituted solution. Keep it refrigerated at 2–8°C, protected from light, avoid freeze–thaw cycles, and use it promptly; discard any solution that turns cloudy or shows particles. Bacteriostatic water contains 0.9% benzyl alcohol as an antimicrobial preservative for multi-draw vials; the preservative does not slow chemical degradation of the peptide itself.
- What is your shipping policy?
- Standard same-day shipping is $7.99 on all orders placed before 4 PM CT, Monday through Thursday. Orders of $200 or more ship free. All orders ship from Austin, TX with tracking provided. We ship to all 50 US states.
All products currently listed on this site are for research purposes only. U.S. sourced. Not intended for human dosing, injection, or ingestion.