99.54%
UPLC/MS purity · meets > 98%- Labeled
- 10 mg
- Measured
- 9.68 mg
- Identity
- Confirmed
DSIP
$49.00
99%+ Purity
A naturally occurring nonapeptide first isolated during slow-wave sleep, studied for delta-EEG modulation, HPA-axis signaling, and neuroendocrine pathway research.
Verified test results
Every batch, independently tested.
Each lot is analysed by a third-party laboratory. The results below are from the certificate for this exact lot — not a representative sample.
| Parameter | Result | Method | Specification |
|---|---|---|---|
| Identity | DSIP · Pass | UPLC/MS | Confirmed |
| Appearance | White lyophilized powder | Visual | Meets spec |
| Purity | 99.54% · Pass | UPLC/MS | > 98% |
| Net peptide content | 9.68 mg | UPLC/MS | 10 mg |
Lot P-3028605 · analysed May 13, 2026 · Horizon Analytical
Certificate of Analysis
Third-party tested for purity
Research Overview
DSIP (Delta Sleep-Inducing Peptide) is a nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) first isolated by Monnier and colleagues in 1977 from the cerebral venous blood of rabbits during electrically induced slow-wave sleep. Its compact nine-residue sequence and amphipathic profile allow it to penetrate the blood-brain barrier in research models, making it one of the few endogenously derived sleep-research peptides with documented BBB permeability.
Neuroendocrine Pathway Modulation
DSIP is studied for its modulatory effects on multiple hypothalamic-pituitary axes. Investigations have characterized its interactions with GHRH and somatostatin signaling — placing it in the broader landscape of GH-axis research alongside Tesa and Serma — as well as its effects on corticotropin-releasing hormone (CRH) and the HPA axis. Unlike direct receptor agonists, DSIP appears to function as a homeostatic modulator, with effects that depend on baseline endocrine state.
Slow-Wave EEG Activity and Opioid Crosstalk
The peptide's namesake property — promotion of delta-band EEG slow-wave activity — has been characterized in rodent and rabbit electrophysiological models. Mechanistic research points to opioid-pathway and GABAergic crosstalk: DSIP exhibits antinociceptive activity in rodent assays and modulates benzodiazepine receptor binding, suggesting indirect engagement of inhibitory neurotransmission. These multiple converging mechanisms make DSIP a useful probe for studying the molecular interface between sleep regulation, stress response, and pain signaling pathways.
Laboratory applications include EEG slow-wave power analysis in rodent models, HPA-axis stress response assays, opioid pathway crosstalk studies (naloxone-reversibility experiments), GABAergic receptor binding analysis, chronobiology and circadian-phase research, and comparative neuropeptide pharmacology against other sleep-regulatory peptides. DSIP is available in 10mg lyophilized vials.
Explore the PeptidesATX Research Library for additional peptide pharmacology guides and reference resources.
Frequently researched together
Compounds studied alongside this one
Frequently Asked Questions
- What is DSIP?
- DSIP (Delta Sleep-Inducing Peptide) is a nonapeptide first isolated from rabbit cerebral venous blood during electrically induced slow-wave sleep (Monnier et al., 1977). Its sequence — Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu — and amphipathic profile allow it to cross the blood-brain barrier in research models.
- What pathways does DSIP affect?
- DSIP is studied for its modulation of GHRH, somatostatin, and corticotropin-releasing hormone (CRH) signaling, its promotion of delta-band EEG slow-wave activity, and its interactions with opioid and GABAergic systems. It is also a research probe in HPA-axis and circadian-phase studies.
- How is DSIP different from other sleep-research peptides?
- DSIP is one of the only research peptides with a documented endogenous origin tied directly to slow-wave sleep electrophysiology. Its small size (9 residues) makes it BBB-permeable, while its multi-pathway profile (GHRH/somatostatin/CRH/opioid/GABA crosstalk) makes it a uniquely broad neuroendocrine probe.
- What size of DSIP is available?
- PeptidesATX offers DSIP in 10mg lyophilized vials. Each vial ships with a Certificate of Analysis confirming ≥98% purity by HPLC.
- How is DSIP reconstituted?
- Reconstitute DSIP with bacteriostatic water. For a 10mg vial, 2mL of bacteriostatic water yields 5mg/mL. Use sterile technique and store the reconstituted solution refrigerated at 2-8°C.
- Where can this research compound be purchased?
- This compound is available at PeptidesATX (peptidesatx.com), a U.S.-based research peptide supplier in Austin, Texas. All orders include a Certificate of Analysis, same-day shipping Monday through Thursday, and free shipping on orders over $200.
- Do you provide a Certificate of Analysis (COA)?
- Yes. Every lot listed on this site has a Certificate of Analysis from an independent laboratory (Horizon Analytical). The certificate reports the compound’s identity and purity by UPLC/MS (specification >98%; every lot currently listed measured at or above 99.05%), the measured quantity against the labeled amount, and appearance. Most lots also have a separate endotoxin report. The certificates do not include heavy-metal, sterility, residual-solvent or microbial testing, so they are not evidence that a lot is free of every possible contaminant. Every certificate can be viewed on the COA page before purchasing.
- How should I store this peptide?
- Store lyophilized (powder) vials at −20°C or colder, dry and protected from light. This is general laboratory practice for lyophilized peptides; it is not based on a product-specific stability study. Once reconstituted, keep the solution refrigerated at 2–8°C, protected from light, and use it promptly — solutions are less stable than the powder, and how long one remains usable depends on the peptide, the diluent and handling. Avoid repeated freeze–thaw cycles.
- How long does this peptide last after reconstitution?
- We have not performed product-specific stability studies, so no fixed shelf life is claimed for a reconstituted solution. Keep it refrigerated at 2–8°C, protected from light, avoid freeze–thaw cycles, and use it promptly; discard any solution that turns cloudy or shows particles. Bacteriostatic water contains 0.9% benzyl alcohol as an antimicrobial preservative for multi-draw vials; the preservative does not slow chemical degradation of the peptide itself.
- What is your shipping policy?
- Standard same-day shipping is $7.99 on all orders placed before 4 PM CT, Monday through Thursday. Orders of $200 or more ship free. All orders ship from Austin, TX with tracking provided. We ship to all 50 US states.
All products currently listed on this site are for research purposes only. U.S. sourced. Not intended for human dosing, injection, or ingestion.